[BCG revaccination in schoolchildren: a pioneer study].
نویسنده
چکیده
* Professor Adjunto do Departamento de Pediatria da Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ). Presidente do Departamento Científico de Pneumologia da SBP. O primeiro de julho é o Dia da Vacina BCG. O fato de existir uma data comemorativa para a vacina demonstra a sua importância na história da humanidade. Essa vacina encerra inúmeras controvérsias desde que foi empregada pela primeira vez em humanos, em 1921, em uma maternidade de Paris, por iniciativa de Calmette, assim coroando a laboriosa experiência iniciada em 1901 por Nocard e Guérin. Esse produto imunibiológico fôra obtido pela atenuação do Mycobacterium bovis após treze anos de pesquisas, sofreu inúmeras resistências a seu uso na população, e mais tarde foi denominado bacilo de Calmette e Guérin1. Para se ter noção da manifestação popular de então, são conhecidas as charges da imprensa em que se vê pessoas vacinadas com BCG passando a ter feições de bovinos, ridicularizando a vacina e amedrontando a população.
منابع مشابه
BCG Revaccination Does Not Protect Against Leprosy in the Brazilian Amazon: A Cluster Randomised Trial
BACKGROUND Although BCG has been found to impart protection against leprosy in many populations, the utility of repeat or booster BCG vaccinations is still unclear. When a policy of giving a second BCG dose to school children in Brazil was introduced, a trial was conducted to assess its impact against tuberculosis, and a leprosy component was then undertaken in parallel. OBJECTIVE to estimate...
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OBJECTIVE To investigate the influence of BCG vaccination or revaccination on tuberculin skin test reactivity, in order to guide the correct interpretation of this test in a setting of high neonatal BCG vaccination coverage and an increasing BCG revaccination coverage at school age. METHODS We conducted tuberculin skin testing and BCG scar reading in 1 148 children aged 7-14 years old in the ...
متن کاملProtocol for a Systematic Review: Bacillus Calmette- Guerin (BCG) Revaccination and Protection Against Tuberculosis
Background: The length of the protective efficacy of BCG vaccine plays an important role in the establishment of vaccination policies. Revaccination with two or more doses is supposed to boost up the immunity. However, the effectiveness of BCG revaccination has been questioned. It was argued that revaccination may increase the rate of tuberculin conversion but does it result in more sustained r...
متن کامل[Continuing or discontinuing BCG revaccination in adolescents].
BCG revaccination was introduced in Brazil in the mid-90's but no study has evaluated vaccine coverage through direct assessment of the scar. BCG scars were assessed in 2,785 public school adolescents, aged 13 to 14 years, in Southeastern Brazil, between September 2001 and May 2002. The prevalence rate of revaccination was 64.3% (95% CI: 62.5-66.0). Despite the efforts to implement and sustain ...
متن کاملSelection bias: neighbourhood controls and controls selected from those presenting to a Health Unit in a case control study of efficacy of BCG revaccination
BACKGROUND In most case control studies the hardest decision is the choice of the control group, as in the ideal control group the proportion exposed is the same as in the population that produced the cases. METHODS A comparison of two control groups in a case control study of the efficacy of BCG revaccination. One group was selected from subjects presenting to the heath unit the case attende...
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ورودعنوان ژورنال:
- Jornal de pediatria
دوره 78 4 شماره
صفحات -
تاریخ انتشار 2002